The renowned mathematician Sir. Asutosh Mukherjee with a deep dream did establish this college. Asutosh College is affiliated under University of Calcutta. The college has a rich heritage that contributes to its own culture. The College was built up in the year 1916 under the leadership of Sir Asutosh Mukherjee, the famous mathematician, educationist and the then Vice-Chancellor of the University of Calcutta. The College was then known as South Suburban College and was housed at a rented premise. When Sir Asutosh passed away in 1924, the college was renamed after him.

The Asutosh College shifted to its current location in 1935. The present college building has a premise of forty thousand square feet and more than fifty classrooms which can contain about 4000 students. Twenty-seven subjects are taught as Honors/Major at the Undergraduate level. In the year 2002, a post graduation course in Environmental Science was introduced. All the departments have their own libraries and well-organized laboratories for Science departments.